Rare cases of allergic reaction to calcipotriol have been reported. Worsening of psoriasis can occur. Side effects from calcipotriol are generally local and include dryness, itching, burning, irritation, thinning of the skin, spider veins, stretch marks, various types of skin rashes and red, swollen hair follicles. If applied to the face, an acne-like rash and swelling can occur. In rare cases, adrenal glands may stop working properly. Rare and serious side effects include pustular psoriasis, adrenal effects and skin thinning. Very rare serious side effects include allergic reaction and high blood calcium levels).